Werner Schroth Selected Research

Cytochrome P-450 CYP2D6 (CYP2D6)

3/2022	(Z)-Endoxifen and Early Recurrence of Breast Cancer: An Explorative Analysis in a Prospective Brazilian Study.
1/2020	The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer.
1/2020	Obesity Alters Endoxifen Plasma Levels in Young Breast Cancer Patients: A Pharmacometric Simulation Approach.
1/2017	Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen.
1/2013	Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters.
1/2013	Association of CYP2D6 metabolizer status with mammographic density change in response to tamoxifen treatment.
3/2012	Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites.
9/2010	CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification.
10/2009	Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.
1/2008	Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer.

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Werner Schroth Research Topics

Disease

31	Breast Neoplasms (Breast Cancer) 06/2022 - 03/2005
11	Neoplasms (Cancer) 06/2022 - 12/2008
1	Inflammation (Inflammations) 12/2020
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 12/2020
1	Body Weight (Weight, Body) 01/2020
1	Obesity 01/2020
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Carcinogenesis 01/2019
1	Triple Negative Breast Neoplasms 06/2017
1	Hepatocellular Carcinoma (Hepatoma) 11/2015
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2013
1	Female Infertility 03/2012
1	Infertility (Sterility) 03/2012
1	Glioblastoma (Glioblastoma Multiforme) 12/2010
1	Leukemia 12/2010
1	Giant Cell Arteritis (Horton Disease) 10/2009
1	Polymyalgia Rheumatica (Rhizomelic Pseudopolyarthritis) 10/2009
1	Carcinoma (Carcinomatosis) 12/2008
1	Colorectal Neoplasms (Colorectal Cancer) 12/2007
1	Breast Diseases (Breast Disease) 03/2005

Drug/Important Bio-Agent (IBA)

19	Tamoxifen FDA LinkGeneric 03/2022 - 11/2007
11	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 03/2022 - 11/2007
8	Estrogen ReceptorsIBA 12/2020 - 12/2008
6	4-hydroxy-N-desmethyltamoxifenIBA 03/2022 - 11/2007
5	Hormones (Hormone)IBA 12/2020 - 01/2008
4	Pharmaceutical PreparationsIBA 06/2022 - 03/2012
4	DNA (Deoxyribonucleic Acid)IBA 12/2010 - 03/2005
3	Progesterone Receptors (Progesterone Receptor)IBA 12/2020 - 12/2010
3	Estrogens (Estrogen)FDA Link 03/2018 - 07/2008
3	EnzymesIBA 05/2013 - 11/2007
3	Estrogen Receptor alphaIBA 12/2010 - 12/2008
2	Aromatase InhibitorsIBA 12/2020 - 11/2013
2	Biomarkers (Surrogate Marker)IBA 12/2020 - 12/2010
2	SteroidsIBA 01/2016 - 01/2008
2	Cytochrome P-450 CYP2C19IBA 01/2016 - 11/2007
2	ParaffinIBA 09/2011 - 12/2010
2	Formaldehyde (Formol)FDA Link 09/2011 - 12/2010
2	RNA (Ribonucleic Acid)IBA 09/2011 - 12/2010
2	Messenger RNA (mRNA)IBA 12/2010 - 12/2008
2	Proteins (Proteins, Gene)FDA Link 11/2009 - 12/2007
2	afimoxifene (hydroxytamoxifen)IBA 10/2009 - 11/2007
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 01/2022
1	Potassium Channels (Potassium Channel)IBA 01/2019
1	ErbB Receptors (EGF Receptor)IBA 01/2017
1	Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)IBA 01/2017
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2017
1	N,N-didesmethyl-4-hydroxytamoxifenIBA 01/2016
1	Progesterone FDA LinkGeneric 01/2016
1	MicroRNAs (MicroRNA)IBA 11/2013
1	Letrozole (Femara)FDA LinkGeneric 11/2013
1	Methanol (Carbinol)IBA 11/2013
1	Clomiphene (Clomifene)FDA LinkGeneric 03/2012
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 09/2011
1	Metalloproteases (Metalloproteinases)IBA 12/2010
1	Deoxyribonuclease I (Nickase)IBA 12/2010
1	Epoxide HydrolasesIBA 12/2010
1	Nucleic AcidsIBA 12/2010
1	Xylenes (Xylene)IBA 12/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2010
1	Protein Isoforms (Isoforms)IBA 11/2009
1	GlucocorticoidsIBA 10/2009
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 10/2009
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2008
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2007
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 11/2007
1	Fluorouracil (Carac)FDA LinkGeneric 07/2007
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/2007
1	AnthracyclinesIBA 07/2007
1	DNA Repair EnzymesIBA 07/2007
1	Methotrexate (Mexate)FDA LinkGeneric 07/2007

Therapy/Procedure

12	Therapeutics 01/2022 - 01/2008
3	Drug Therapy (Chemotherapy) 11/2015 - 07/2007
2	Lasers (Laser) 09/2010 - 12/2007
1	Precision Medicine 06/2022
1	Isogeneic Transplantation 01/2022
1	Transplantation 01/2017
1	Adjuvant Chemotherapy 07/2007